Pd–Phosphine Precatalysts for Modern Cross-Coupling Reactions - New Trends in Cross-Coupling: Theory and Applications - page 132

X

OR

NH 2
L
OMs

126, 127

+ ROH

L= t BuBrettPhos,
RockPhos, Cy 3 t BuBrettPhos

n

n

Pd

Y

Y

X

NH 2

L=AdBrettPhos,
Me 3 (OMe)XPhos,
Me 3 (OMe)PhXPhos

NH 2
L
OMs

+

128

NH 3

n

n

Pd

Y

Y

X=Cl,Br

R

X H 2 N

L= t BuBrettPhos

NH 2
L
OMs

O

O

127 Pd

+

n

n H 2 NR

Y

Y

X=Cl

ZnCl HetAr

L=XPhos

NH 2
L
OMs

+ HetArX

129

n

n

Y Pd

Y

X=I,Br,Cl,OTf

X

R

+ R

(t-Bu 3 P) 2 Pd 133, 134

Y

Y

X=Br,Cl

Br

[(p-Me 2 NC 6 H 4 (t-Bu) 2 P] 2 Pd 135, 136

R

+

R

ZnI

O

R'OH
or
R' 2 NH

Cl

(dcpp) 2 PdCl 2 88

CO OR'

R

R

+ or

NR' 2