Chemistry Reference
In-Depth Information
CHAPTER 3
Pd-Phosphine Precatalysts for
Modern Cross-Coupling
Reactions
CARIN C. C. JOHANSSON SEECHURN,
a
HONGBO LI
b
AND
THOMAS J. COLACOT*
b
a
Johnson Matthey Catalysis and Chiral Technologies, Orchard Road,
Royston SG8 5HE, UK;
b
Johnson Matthey Catalysis and Chiral
Technologies, 2001 Nolte Drive, West Deptford, NJ 08066, USA
*Email: thomas.colacot@jmusa.com
3.1 Introduction
Over the last few decades, the real-world applications of palladium-catalyzed
cross-coupling have continuously expanded into many areas of chemistry,
such as the synthesis of natural products,
1
active pharmaceutical ingredients
(APIs),
2
agrochemicals,
3
monomers for polymers
4
and advanced materials
for electronic applications.
5
A historical perspective on the development of
cross-coupling reactions in the light of the 2010 Nobel Prize in Chemistry
was recently reviewed by our group in collaboration with Snieckus and co-
workers.
6
Concurrently, a more focused review on the theory behind the
preformed catalyst development was also published by our group.
7
There-
fore, in this chapter we have tried our best not to duplicate those efforts, but
to discuss the developments and applications of L
2
Pd- and LPd-based pre-
formed catalysts from a reactivity and selectivity point of view, while pro-
viding the theoretical understanding in making the catalyst selection for a
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