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Br
O
Pd(OAc)
2
(5 mol %)
Ligand (6 mol %)
K
3
PO
4
O
P
O
t
-Bu
B(OH)
2
MeO
OMe
N
N
R
THF, rt
O
O
O
O
Ligand
85 - 96 % Yield
up to 96 % ee
Figure 2.70 Asymmetric Suzuki-Miyaura coupling using a P,C-stereogenic ligand.
Br
Pd(OAc)
2
(3 mol %)
Ligand (9 mol %)
Cs
2
CO
3
O
n
R
1
R
1
CHO
PAr
2
N
n
CHO
t
-Bu
Ar = 4-OMeC
6
H
4
t
BuOH, 80 °C
R
2
R
2
53 - 87 % Yield
up to 98 % ee
Ligand
Figure 2.71 Asymmetric intramolecular a-arylation of aldehydes using a phox ligand.
Pd(dba)
2
(3 mol %)
(
S
)-
t
-Bu-phox (6 mol %)
(
i
-Pr)
2
NEt
TfO
O
O
O
THF, 70 °C
PPh
2
N
87 % Yield
97 % ee
t
-Bu
(
S
)-
t
Bu-phox
Figure 2.72 Enantioselective Heck reaction employing (S)-t-Bu-phox.
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