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MgBr
Bn
PdCl
2
[(
S
)-Phephos] (5 mol %
)
NMe
2
TfO
OTf
Ph
OTf
Ph
Ph
Et
2
O/toluene,
−
30 °C
PPh
2
(
S
)-Phephos
87 %
93 % ee
(13 %)
Figure 2.62 Enantioselective biaryl formation with PdCl
2
[(S)-Phephos].
Ni(COD)
2
(5 mol %)
(
S
)-BINAP (8.5 mol %)
NaHMDS
toluene/THF, 60 °C
25 - 91 %
O
O
R
ArBr or ArCl
R
O
O
Ar
(
83 99 % ee
)
Figure 2.63 Enantioselective a-arylation of lactones using Ni/(S)-BINAP.
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