Polynucleotides and Single-Stranded DNA Fragments - Free-Radical-Induced DNA Damage and Its Repair - page 339

al. 1998). This is in agreement with an ALS such as 2-dRL being the major prod-
uct. The nature of the direct SSB that occurs at the same site remains an open
question.
A higher level of strand breakage is observed in the absence of O 2 , and a
markedly different pattern of 3 -termini damage is observed. It has been sug-

gested that in the presence of O 2 Ura-5-peroxyl radicals may play a role (for its
complex chemistry see Chap. 10.7), but details are not yet understood.

′

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