Nucleobases, Nucleosides and Nucleotides - Free-Radical-Induced DNA Damage and Its Repair - page 292

The release of free base (see also Hoffman and Hüttermann 2000) and the forma-
tion of 2-dRL results from a damage of the sugar moiety, but there are a host of

further products altered at the sugar moiety.
The formation of the cyclonucleosides shown below (for their synthesis see Ro-
mieu et al. 1999b) shows that the addition of the C (5 ′ ) radical can also add to

the C (5) − C (6) Thy double bond [the corresponding Cyd case has been discussed

above in reactions (195) and (196)].
In the irradiation of solid Thd the formation of • H-adducts is established (see
above), and it is thus not surprising that H 2 Thd (and also H 2 Thy; secondary
product?) are also among the products.
Similar experiments have been carried out with dGuo (Gromova et al. 1998).
The free base, 2-dRL sugar lesions of analogous to those reported above (now