Nucleobases, Nucleosides and Nucleotides - Free-Radical-Induced DNA Damage and Its Repair - page 235

γ -Radiolysis of dGuo (5 × 10 −3 mol dm −3 ) in deaerated and N 2 O-saturated
solutions. Products and their G values (unit: 10 −7 mol J −1 ; Berger and Cadet 1985)

Table 10.13.

Product N 2 N 2 O

N 6 -(2 ′ -Deoxy- α - D - erythro -pentopyranosyl)-2,6-diamino-5-
formamidopyrimid-4-one (

0.27 0.26

α -FAPY-G)

N 6 -(2 ′ -Deoxy- β - D - erythro -pentopyranosyl)-2,6-diamino-5-
formamidopyrimid-4-one ( β -FAPY-G)

0.09 0.1

5 ′ -8-Cyclo-2 ′ ,5 ′ -dideoxyguanosine 0.05 0.06

8-oxo-G - 0.25

Gua 0.2 0.4

9-(2 ′ -Deoxy- α - D - erythro -pentopyranosyl)guanine 0.02 0.03

9-(2 ′ -Deoxy- β - D - erythro -pentopyranosyl)guanine 0.01 0.02

9-(2 ′ -Deoxy- α - D - erythro -pentofuranosyl)guanine 0.02 0.02

9-(2 ′ -Deoxy- α - L - threo -pentofuranosyl)guanine 0.02 0.02

9-(2 ′ -Deoxy- β - D - erythro -pento-1,5-dialdo-1,4-pyranosyl)-guanine 0.07 0.08

a a

2-Deoxyribonolactone, 2-dRL

dGuo consumption 0.83 1.6

a Observed, but not quantified

γ -Radiolysis of Ade (2 × 10 −3 mol dm −3 ) in N 2 O-saturated solutions. Products
and their G values (unit: 10 −7 mol J −1 ; van Hemmen and Bleichrodt 1971; see also van Hem-
men 1971)

Table 10.14.

Product G value

4,6-Diamino-5-formamidopyrimidine (FAPY-A) 0.2

8-Hydroxyadenine (8-oxo-A) 0.35

6-Amino-8-hydroxy-7,8-dihydropurine 0.1

Ade consumption 1.0