Nucleobases, Nucleosides and Nucleotides - Free-Radical-Induced DNA Damage and Its Repair - page 206

Table 10.3. Compilation of rate constants (unit: dm 3 mol −1 s −1 ) of oxidizing radicals with
nucleobases and related compounds

Substrate Radical Rate constant Reference

SO 4 • − 10 9

Ade 4.6 × Vieira and Steenken (1987a)

SO 4 • − 4.1 × 10 9 9MeAde Vieira and Steenken (1987a)

3.2 × 10 9
4 × 10 5

dAdo

SO 4 • −
Br 2 • −

Steenken (1989)
von Sonntag (1994)

dAdo/H + (pH 2.4) SO 4 • − 4.4 × 10 9 Steenken (1989)

Ado

2.7 × 10 9
6.3

Vieira and Steenken (1987a)
Al-Sheikhly (1994)

SO 4 • −
Tl(II)

10 7 ×

N 6 , N 6 Me 2 Ado SO 4 • − 3.9 × 10 9 Vieira and Steenken (1987a)

SO 4 • − 2.5 × 10 8

1.6 × 10 9

dCyd O'Neill and Davies (1987)

Aravindakumar et al. (2003)

SO 4 • − 10 9 Cyd 3 × Aravindakumar et al. (2003)

SO 4 • − 7. 5 × 10 8

Cyt anion Hazra and Steenken (1983)

Cy t /H + (pH 2) Cl 2 • − 1.0 × 10 7 Patterson et al. (1972)

dCyd/H + (pH 2) Cl 2 • − 4 × 10 6 Patterson et al. (1972)

• N 3

4 × 10 9

Gua anion Faraggi and Klapper (1994)

dGuo

SO 4 • −
SeO 3 • −

2.3 × 10 9
4.1 × 10 9
1.2 × 10 9

O'Neill and Davies (1987)
Steenken (1989)
Martin and Anderson (1998)

• N 3

4 × 10 9 dGuo anion Faraggi and Klapper (1994)

(Me 4 Thiourea) 2 • + 1.2 × 10 8

Schuchmann et al. (2000)

Br 2 • − 4 × 10 7

dGMP Willson et al. (1974)

1.26 × 10 9 Guo Tl(II) Al-Sheikhly (1994)

SO 4 • −
Cl 2 • −
HPO 4 • −

3.1 × 10 9
7. 0 × 10 7
9.6

Thy Fujita et al. (1988)

Patterson et al. (1972)
Nakashima and Hayon (1979) 10 7 ×

SO 4 • − 2.1 × 10 9 Thd Deeble et al. (1990)

SO 4 • − 3.5 × 10 9 3MeThd Deeble et al. (1990)

SO 4 • − 1 × 10 9

TMP Deeble et al. (1990)

SO 4 • − 10 9 1MeThy 5 × Deeble et al. (1990)

SO 4 • − 4.6 × 10 9

1,3Me 2 Thy Deeble et al. (1990)

Cl 2 • −
HPO 4 • −
H 2 PO 4 •

3.5 × 10 7
9.7 × 10 7
6 × 10 8

Ura Patterson et al. (1972)

Nakashima and Hayon (1979)
Nakashima and Hayon (1979)

SO 4 • − 5.5 × 10 9

1,3Me 2 Ura Schuchmann et al. (1987)

SO 4 • − 3.5 × 10 9 1,3,6Me 3 Ura Deeble et al. (1990)