Biomedical Engineering Reference
In-Depth Information
2
Principles of Clinical and Engineering
Integration
in Hemocompatibility
Yitzhak Rosen, Noel Elman
CONTENTS
Overview .................................................................................................................. 5
Questions That Should Be Addressed ............................................................. 8
The Patient ........................................................................................................... 8
Genetic Polymorphism and Individual Variability: Focus on Cardiac
Stents ..................................................................................................................... 9
CardioGene Study ............................................................................................ 10
Polymorphisms in Inflammation and Proliferation Effects on
In-Stent Stenosis ............................................................................................... 10
Platelet Receptor Genes ................................................................................... 12
Adjunct Therapy Resistance Stratification ................................................... 12
Endothelial Cell Trafficking Stratification..................................................... 13
Special Clinical States ........................................................................................... 14
Pregnancy .......................................................................................................... 14
Autoimmune States.......................................................................................... 15
Cancer ................................................................................................................ 17
Biodegradable and Bioabsorbable Cardiac Stents ............................................ 18
Should Cardiac Stents Be Biodegradable/Bioabsorbable?......................... 19
Overview ...................................................................................................... 19
Bioabsorbable Stents ................................................................................... 20
Drug-Eluting Balloons (DEB) .............................................................................. 21
Conclusion ............................................................................................................. 23
References ............................................................................................................... 23
Overview
Hemocompatibility, compatibility when coming into contact with blood,
is an important component of biocompatibility [1, 2]. It is also a great
example where clinical and engineering integration is critical. Many
life-saving devices come into contact with blood, whether permanently
5
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