Endocrine-Disrupting Pesticides - Pesticides: Evaluation of Environmental Pollution - page 621

TABLE 20.2
Representative Endocrine Actions of DDT and Its Metabolites in Vertebrates

Compound Label Effect Effect Study Type References

Not Specified DDT
DDT

Antiandrogenic Altered testosterone

metabolism

Birds Peakall (1967)

DDT Altered thyroxine

metabolism

Birds Bastomsky (1974)

DDT Altered progesterone

metabolism

Birds Peakall (1967)

Technical DDT
DDT Estrogenic Estrogenic response cells E-screen Sonnenschein and

Soto (1998)

DDT Estrogenic Increase uterine weight Rat Welch et al. (1969)

DDT Antiestrogenic Antagonized estrogenic

treatment

Tiger salamander Clark et al. (1998)

DDT Increases steroid

metabolism

Rat (liver) Welch et al. (1969)

DDT (2 isomers)
o,p′-DDT Estrogenic? ER interaction Alligator ER Vonier et al. (1996)

o,p′-DDT Estrogenic? Weakly binds ER Human ER Gaido et al. (1997)

o,p′-DDT Estrogenic Induction of zona radiata

proteins

Atlantic salmon Arukwe et al. (1997)

Estrogenic Estrogenic response cells E-screen Sonnenschein and

Soto (1998)

o,p′-DDT

o,p′-DDT Estrogenic ER binding + response Mice ER Shelby et al. (1996)

o,p′-DDT Estrogenic Increase in uterine weight Rat Welch et al. (1969)

o,p′-DDT Estrogenic Vtg synthesis in males Red eared turtle Palmer and Palmer

(1995)

o,p′-DDT Estrogenic Induction of Vtg/hepatic

EBS

Trout Donohoe and Curtis

(1996)

o,p′-DDT Estrogenic ER binding + response YES Arnold et al. (1996)

o,p′-DDT Estrogenic ER binding + response YES/CB/MCF-7 Klotz et al. (1996)

o,p′-DDT Antiestrogenic Strong antagonist Rabbit ER (CB) Danzo (1997)

o,p′-DDT Antiandrogenic Antagonist Human AR Maness et al. (1998)

o,p′-DDT Antiandrogenic Strong antagonist Rat AR Danzo (1997)

o,p′-DDT Antiandrogenic Antagonist YES AR Sohoni and Sumpter

(1998)

Hyperthyroidism Increased thyroid weight Bengal finch Jefferies (1969)

o,p′-DDT

o,p′-DDT Estrogenic/

antiandrogenic

Skewed sex ratio toward
female

Seagull Fry and Toone

(1981)

o,p′-DDT Estrogenic/

antiandrogenic

Development of right
oviduct

Seagull Fry and Toone

(1981)

o,p′-DDT Estrogenic/

antiandrogenic

Feminized testis Seagull Fry and Toone

(1981)

p,p′-DDT Estrogenic? Weak ER interaction Alligator ER Vonier et al. (1996)

p,p′-DDT Estrogenic Estrogenic response cells E-screen Sonnenschein and

Soto (1998)
( continued )