Endocrine-Disrupting Pesticides - Pesticides: Evaluation of Environmental Pollution - page 618

TABLE 20.1 (Continued)
Some Suspected Endocrine-Disrupting Pesticides

Affected Hormone
System Compound Mechanism References

Malathion Thyroid Decrease of thyroid hormone

in serum, with perhaps a
direct effect on the thyroid
gland

Akhtar et al. (1996)

Mancozeb Thyroid Thyroid peroxidase inhibitor Hurley et al. (1998)

Maneb Thyroid The metabolite

ethylenethiourea inhibits
thyroid hormone synthesis

Toppari et al. (1995)

Methomyl Thyroid Porter et al. (1993) and

Klotz et al. (1997b)

Metribuzin Thyroid Porter et al. (1993)

Nitrofen Thyroid Structural similarities to

the thyroid hormones;
nitrofen or its metabolite
may have thyroid
hormone activities

Stevens and Summer
(1991)

Pendimethalin Thyroid Enhances secretion of thyroid

hormone

Hurley et al. (1998)

Pentachloronitrobenzene Thyroid Enhances secretion of thyroid

hormone

Hurley et al. (1998)

Prodiamine Thyroid Enhances secretion of thyroid

hormone

Hurley et al. (1998)

Pyrimethanil Thyroid Enhances secretion of thyroid

hormone

Hurley et al. (1998)

Talstar Thyroid A decrease of thyroid

hormone in serum; direct
effect on the thyroid
gland?

Akhtar et al. (1996)

Thiazopyr Thyroid Enhances secretion of thyroid

hormone

Hurley et al. (1998)

Zineb Thyroid The metabolite

ethylenethiourea inhibits
thyroid hormone synthesis

Toppari et al. (1995)

Ziram Thyroid Inhibits the iodide

peroxidase
Structural similarities
between ziram and thiram;
ziram can be metabolized to
thiram in the environment

Marinovich et al. (1997)

Acetochlor Thyroid (decrease of

thyroid hormone
levels, increase in
TSH

Hurley et al. (1998)

Alachlor Thyroid (decrease of

thyroid hormone
levels, increase in
TSH

Wilson et al. (1996)

Source: Taken from the website Our Stolen Future.