Endocrine-Disrupting Pesticides - Pesticides: Evaluation of Environmental Pollution - page 617

TABLE 20.1 (Continued)
Some Suspected Endocrine-Disrupting Pesticides

Affected Hormone
System Compound Mechanism References

Kepone (chlordecone) Estrogen Displays androgen- and

estrogen-receptor-binding
affinities

Waller et al. (1996),
Lambright et al. (2000),
and Gray et al. (1999)

Lindane
(hexachlorocyclohexane)

Estrogen
Androgen

Inhibits ligand binding to
androgen and estrogen
receptors

Danzo (1997)

Methoxychlor Estrogen Through mechanisms other

than receptor antagonism
Precise mechanism still
unclear

Pickford and Morris
(1999)

Nonachlor, trans- Estrogen Estrogen-receptor agonist Willingham et al. (2000)

Toxaphene Estrogen

Thyroid

Soto et al. (1994)

Triadimefon Estrogen Estrogen-receptor agonist Vinggaard et al. (1999)

Triadimenol Estrogen Estrogen-receptor agonist Vinggaard et al. (1999)

Carbaryl Estrogen and

progesterone

Klotz et al. (1997b)

Permethrin Estrogenic Go et al. (1999)

Iprodione Inhibition of

testosterone synthesis

Benhamed (1996)

Atrazine Neuroendocrine

pituitary (depression
of LH surge),
testosterone
metabolism

Inhibits ligand binding to
androgen and estrogen
receptors

Danzo (1997)

Oxychlordane Reproductive Guillette et al. (1999)

Tributyltin Reproductive Horiguchi et al. (2000)

Trifluralin Reproductive

metabolic

Rawlings et al. (1998)

Chlordane Testosterone and

progesterone

Willingham et al. (2000)

Amitrole Thyroid Thyroid peroxidase inhibitor

inhibits thyroid hormone
synthesis

Hurley et al. (1998)

Clofentezine Thyroid Enhances the secretion of

thyroid hormone

Hurley et al. (1998)

Ethylene thiourea Thyroid Thyroid peroxidase inhibitor Hurley et al. (1998)

Fenbuconazole Thyroid Enhances the secretion of

thyroid hormone

Hurley et al. (1998)

Fipronil Thyroid Enhances the secretion of

thyroid hormone

Hurley et al. (1998)

Heptachlor Thyroid Akhtar et al. (1996) and

Reuber (1987)

Heptachlor epoxide Thyroid

Reproductive

Reuber (1987)

Karate Thyroid Decrease of thyroid hormone

in serum; direct effect on the
thyroid gland?

Akhtar et al. (1996)

( continued )