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d n 2 r 4 n g | 8
.
Figure 5.9 FESEM images of P(3HB-co-4HB) (a: surface morphology; b: cross-section
morphology), BC (c: surface morphology; d: cross-section morphology)
and P(3HB-co-4HB)/BC nanocomposite scaffolds (e: surface morphology;
f: cross-section morphology).
Reprinted from Zhijiang et al. 58 with permission from Elsevier.
5.4 Applications of PHA Nanocomposites
As highlighted earlier, the incorporation of nanofillers into PHAs extends
their application ranges while retaining their excellent biodegradability and
compatibility. Recently, various types of biopolymer nanocomposites with
properties suitable for a wide range of applications were prepared and
characterized. 17,34,42,58,60 The poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/
bacterial cellulose nanocomposite was used as a scaffold to eciently cul-
tivate Chinese hamster lung (CHL) fibroblast cells. 58 A nanocomposite based
on poly-3-hydroxybutyrate and bioglass with high porosity was reported to be
a potential candidate for bone tissue scaffolds (Table 5.2). 36 Smart drug
delivery devices are normally composed of a targeting ligand that can direct
the drug carrier to the specific site. In human cancer cells, a high expression
 
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