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phosphoinositide 3-kinase/Akt signal trans-
duction pathway by mass spectrometry.
Proc.
Natl. Acad. Sci. USA
103
, 8959-8964.
3. Cascante, M., Boros, L. G., Comin-Anduix,
B., de Atauri, P., Centelles, J. J., and Lee,
P. W. (2002) Metabolic control analysis in
drug discovery and disease.
Nat. Biotechnol.
20
, 243-249.
4. Comin-Anduix, B., Boren, J., Martinez, S.,
Moro, C., Centelles, J. J., Trebukhina, R.,
Petushok, N., Lee, W. N., Boros, L. G.,
and Cascante, M. (2001) The effect of thi-
amine supplementation on tumour prolifera-
tion. A metabolic control analysis study.
Eur.
J. Biochem.
268
, 4177-4182.
5. Guha, U., Chaerkady, R., Marimuthu, A.,
Patterson, A. S., Kashyap, M. K., Harsha,
H. C., Sato, M., Bader, J. S., Lash, A. E.,
Minna, J. D., Pandey, A., and Varmus, H. E.
(2008) Comparisons of tyrosine phosphory-
lated proteins in cells expressing lung cancer-
specific alleles of EGFR and KRAS.
Proc.
Natl. Acad. Sci. USA
105
, 14112-14117.
6. Kim, J. E., and White, F. M. (2006) Quan-
titative analysis of phosphotyrosine signaling
networks triggered by CD3 and CD28 cos-
timulation in Jurkat cells.
J. Immunol.
176
,
2833-2843.
7. Kruger, M., Kratchmarova, I., Blagoev, B.,
Tseng, Y. H., Kahn, C. R., and Mann, M.
(2008) Dissection of the insulin signaling
pathway via quantitative phosphoproteomics.
Proc. Natl. Acad. Sci. USA
105
, 2451-2456.
8. Larive, R. M., Urbach, S., Poncet, J., Jouin,
P., Mascre, G., Sahuquet, A., Mangeat, P.
H., Coopman, P. J., and Bettache, N. (2009)
Phosphoproteomic analysis of Syk kinase
signaling in human cancer cells reveals its
role in cell-cell adhesion.
Oncogene
28
(24),
2337-2347.
9. Olsen, J. V., Blagoev, B., Gnad, F., Macek,
B., Kumar, C., Mortensen, P., and Mann, M.
(2006) Global, in vivo, and site-specific phos-
phorylation dynamics in signaling networks.
Cell
127
, 635-648.
10. Rikova, K., Guo, A., Zeng, Q., Possemato,
A., Yu, J., Haack, H., Nardone, J., Lee, K.,
Reeves, C., Li, Y., Hu, Y., Tan, Z., Stokes,
M., Sullivan, L., Mitchell, J., Wetzel, R.,
Macneill, J., Ren, J. M., Yuan, J., Bakalarski,
C. E., Villen, J., Kornhauser, J. M., Smith,
B., Li, D., Zhou, X., Gygi, S. P., Gu, T. L.,
Polakiewicz, R. D., Rush, J., and Comb, M.
J. (2007) Global survey of phosphotyrosine
signaling identifies oncogenic kinases in lung
cancer.
Cell
131
, 1190-1203.
11. Rush, J., Moritz, A., Lee, K. A., Guo, A.,
Goss, V. L., Spek, E. J., Zhang, H., Zha,
X. M., Polakiewicz, R. D., and Comb, M. J.
(2005) Immunoaffinity profiling of tyrosine
phosphorylation in cancer cells.
Nat. Biotech-
nol.
23
, 94-101.
12. Trinidad, J. C., Specht, C. G., Thalham-
mer, A., Schoepfer, R., and Burlingame, A.
L. (2006) Comprehensive identification of
phosphorylation sites in postsynaptic den-
sity preparations.
Mol. Cell. Proteomics
5
,
914-922.
13. Villen, J., and Gygi, S. P. (2008) The
SCX/IMAC enrichment approach for global
phosphorylation analysis by mass spectrome-
try.
Nat. Protoc.
3
, 1630-1638.
14. Lienhard, G. E. (2008) Non-functional
phosphorylations?
Trends Biochem. Sci.
33
,
351-352.
15. Greenman, C., Stephens, P., Smith, R., Dal-
gliesh, G. L., Hunter, C., Bignell, G., Davies,
H., Teague, J., Butler, A., Stevens, C.,
Edkins, S., O
Meara, S., Vastrik, I., Schmidt,
E. E., Avis, T., Barthorpe, S., Bhamra, G.,
Buck, G., Choudhury, B., Clements, J., Cole,
J., Dicks, E., Forbes, S., Gray, K., Halli-
day, K., Harrison, R., Hills, K., Hinton, J.,
Jenkinson, A., Jones, D., Menzies, A., Miro-
nenko, T., Perry, J., Raine, K., Richardson,
D., Shepherd, R., Small, A., Tofts, C., Var-
ian, J., Webb, T., West, S., Widaa, S., Yates,
A., Cahill, D. P., Louis, D. N., Goldstraw,
P., Nicholson, A. G., Brasseur, F., Looijenga,
L., Weber, B. L., Chiew, Y. E., DeFazio,
A.,Greaves,M.F.,Green,A.R.,Camp-
bell, P., Birney, E., Easton, D. F., Chenevix-
Trench, G., Tan, M. H., Khoo, S. K., Teh, B.
T., Yuen, S. T., Leung, S. Y., Wooster, R.,
Futreal, P. A., and Stratton, M. R. (2007)
Patterns of somatic mutation in human can-
cer genomes.
Nature
446
, 153-158.
16. Sawyers, C. L. (2008) The cancer biomarker
problem.
Nature
452
, 548-552.
17. Miller, M. L., Jensen, L. J., Diella, F., Jor-
gensen, C., Tinti, M., Li, L., Hsiung, M.,
Parker, S. A., Bordeaux, J., Sicheritz-Ponten,
T., Olhovsky, M., Pasculescu, A., Alexander,
J., Knapp, S., Blom, N., Bork, P., Li, S.,
Cesareni, G., Pawson, T., Turk, B. E., Yaffe,
M. B., Brunak, S., and Linding, R. (2008)
Linear motif atlas for phosphorylation-
dependent signaling.
Sci. Signal.
1
,ra2.
18. Linding, R., Jensen, L. J., Pasculescu, A.,
Olhovsky, M., Colwill, K., Bork, P., Yaffe,
M. B., and Pawson, T. (2008) NetworKIN:
a resource for exploring cellular phospho-
rylation networks.
Nucleic Acids Res.
36
,
D695-D699.
19. Linding, R., Jensen, L. J., Ostheimer, G. J.,
van Vugt, M. A., Jorgensen, C., Miron, I.
M., Diella, F., Colwill, K., Taylor, L., Elder,
K., Metalnikov, P., Nguyen, V., Pasculescu,
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