The Toxicology of 1,4-Dioxane - Environmental Investigation and Remediation - page 249

Male Sprague Dawley rat DNA synthesis in hepatocytes Drinking water; thymidine incorporation ND Stott et al. (1981)

+

Male Sprague Dawley rat DNA repair in hepatocytes Drinking water; thymidine incorporation with hydroxyurea

to repress normal DNA synthesis

ND Stott et al. (1981)

−

Male Sprague Dawley rat DNA alkylation in hepatocytes Gavage; DNA isolation and HPLC analysis 4 h after

dosing

− ND Stott et al. (1981)

Male B6C3F 1 mouse Micronucleus formation in bone

marrow

i.p. injection; analysis of polychromatic erythrocytes 24 or
48 h after dosing

ND McFee et al. (1994)

−

Male and female C57BL6
mice; male BALB/c mouse

Micronucleus formation in bone
marrow

Gavage; analysis of polychromatic erythrocytes 24 or 48 h
after dosing

+
(C57BL6)-
(BALB/c)

ND Mirkova (1994)

Male CD-1 mouse Micronucleus formation in

peripheral blood

Two i.p. injections (one per day); micronucleated
reticulocytes measured 24, 48, and 72 h after the second
dose

− ND Morita (1994)

Male CD-1 mouse Micronucleus formation in

hepatocytes

Gavage; partial hepatectomy 24 h after dosing; hepatocytes
analyzed i ve days after hepatectomy

ND Morita and Hayashi

(1998)

+

Male CD-1 mouse Micronucleus formation in

peripheral blood

Gavage; partial hepatectomy 24 h after dosing; peripheral
blood obtained from tail vein 24 h after hepatectomy

− ND Morita and Hayashi

(1998)

Male CD-1 mouse Micronucleus formation in

hepatocytes and bone marrow

Gavage; analysis of bone marrow erythrocytes and
proliferating BrdU-labeled hepatocytes

ND Roy et al. (2005)

+

Male CBA and C57BL6
mice

Micronucleus formation in bone
marrow

Gavage; analysis of polychromatic erythrocytes from
specimens prepared 24 h after dosing

− ND Tinwell and Ashby

(1994)

Note: + = positive, ± = weak positive, - = negative, T = toxicity, ND = no data.