The Toxicology of 1,4-Dioxane - Environmental Investigation and Remediation - page 246

TABLE 5.4
Genotoxicity Studies with 1,4-Dioxane

Results

Without
Activation

With
Activation

Test System Endpoint Test Conditions References

Bacteria

Salmonella typhimurium
strains TA98, TA100,
TA1535, and TA1537

Reverse mutation Plate incorporation assay Haworth et al. (1983)

− −

Salmonella typhimurium
strains TA98, TA100, TA
1530, TA1535, and TA1537

Reverse mutation Plate incorporation assay − − Khudoley et al. (1987)

Salmonella typhimurium
strains TA98, TA100,
TA1535, and TA1537

Reverse mutation Plate incorporation and preincubation assays Morita and Hayashi

(1998)

− −

Salmonella typhimurium
strains TA100, TA1535

Reverse mutation Preincubation assay − − Nestmann et al. (1984)

Salmonella typhimurium
strains TA98, TA100,
TA1535, TA1537, and
TA1538

Reverse mutation Plate incorporation assay Stott et al. (1981)

− −

E. coli K-12 uvrB/recA DNA repair Host-mediated assay − − Hellmer and Bolcsfoldi

(1992)

E. coli WP2/WP2uvrA Reverse mutation Plate incorporation and preincubation assays Morita and Hayashi

(1998)

− −

P. phosphoreum M169 Mutagenicity, DNA damage Mutatox assay − ND Kwan et al. (1990)