The Toxicology of 1,4-Dioxane - Environmental Investigation and Remediation - page 235

Guinea pig Vapor inhalation 8 h of exposure to 0.1-3 vol% Eye and nasal irritation, retching movements,

altered respiration, narcosis, pulmonary edema
and congestion, hyperemia of the brain

0.5 vol% Yant et al. (1930)

Other Routes
Male COBS/Wistar
rat

Dermal Nonoccluded technique using

shaved areas of the back and
l ank; single application,
14-day observation

Negative; no effects noted 8300 mg/kg Clark et al. (1984)

Rabbit, cat i.v. injection Single injection of 0, 207,

1034, 1600 mg/kg-day

Clinical signs of CNS depression, narcosis at
1034 mg/kg, mortality at 1600 mg/kg

1034 mg/kg-day de Navasquez

(1935)

Rat (strain not
specii ed); rabbit
(strain not
specii ed)

i.p. injection Single dose Narcosis, staggering posture 30 mmol/kg (rat); 50 mmol/kg

(rabbit)

Knoefel (1935)

Female Sprague
Dawley rat

i.p. injection Single dose; LD 50 values

determined 24 h and 14 days
after injection

Increased serum SDH activity at 1/16th of the
LD 50 dose; no change at higher or lower doses

LD 50 (mg/kg): 24 h = 4848,
14 days = 799

Lundberg et al.
(1986)

CBA/J mouse i.p. injection Daily injection for seven days;

0%, 0.1%, 1%, 5%, and 10%

Slightly lower lymphocyte response to mitogens 2000 mg/kg-day (10%) Thurman et al.

(1978)

Notes: ND = no data; OCT = ornithine carbamyl transferase; ODC = ornithine decarboxylase; and SDH = sorbitol dehydrogenase.

a Lowest effective dose for positive results/highest dose tested for negative results.