Biophysical Models of the Cardiovascular System - Systems Biology: Networks, Models, and Applications - page 265

Figure 9.1 (a) Ultrastructure of the cardiac ventricular myocyte, illustrating
the organization of sarcomeres and the T-tubules. (Reproduced from fig. 1.14 of
Katz [92] with permission). (b) Illustration of the physical organization and
channel localization in the cardiac dyad. (Reproduced from fig. 1 of Bers [33]
with permission).
that there are approximately 10 LCCs per dyad [3], ~50,000 active
LCCs per myocyte, and therefore ~5000 dyads per myocyte. As will
be described in a subsequent section, the detailed microstructure of
the dyad has a profound influence on the macroscopic function of
the myocyte.