Biology Reference
In-Depth Information
Maximum
Succinic acid
Succinic
biomass formation
production rate
acid flux
Disrupted genes
rate (h 1 )
(mmol/g DCW/h)
ratio a
Wild-type
0.2156
0.1714
0.002
PykFA
0.2156
0.1714
0.002
PtsG
0.1884
0.1714
0.002
PflB
0.1882
0.857
ldhA
0.2156
0.1714
ptsG pykFA
0.1366
6.834
0.231
ptsG mqo
0.1884
0.1714
ptsG sdhA
0.1884
0.1714
ptsG aceBA
0.1884
0.1714
pykFA sdhA
0.2156
0.1714
pykFA aceBA
0.2156
0.1714
mqo sdhA
0.2156
0.1714
mqo aceBA
0.2156
0.1714
sdhA aceBA
0.2156
0.1714
ptsG pfl ldhA
0.1611
0.6856
ptsG pykF pykA pfl
0.1219
9.1236
0.503
ptsG pykF pykA pfl ldhA
0.1219
9.1236
0.503
a Calculated as succinic acid/(succinic acid
+
lactate
+
formate
+
acetate
+
ethanol).
Figure 7.13 Computationally predicted tradeoff curves for several in silico
mutants. Closed circles, wild-type; open circles, D ptsG ; closed triangles, D pflB ;
open triangles, D ptsG D pykFA ; close squares, D ptsG D pykFA D pflB ; open squares,
D ptsG D pflB D ldhA ; closed diamonds, D ptsG D pykFA D pflB D ldhA under aerobic
condition; open diamonds, D ptsG D pykFA D pflB D ldhA under anaerobic
condition. Abbreviations: ptsG , phosphotransferase systems; pyk , pyruvate
kinase; pflB , pyruvate formate-lyase; ldhA , D -lactate dehydrogenase.
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