Biology Reference
In-Depth Information
Maximum
Succinic acid
Succinic
biomass formation
production rate
acid flux
Disrupted genes
rate (h
−
1
)
(mmol/g DCW/h)
ratio
a
Wild-type
0.2156
0.1714
0.002
PykFA
0.2156
0.1714
0.002
PtsG
0.1884
0.1714
0.002
PflB
0.1882
0.857
—
ldhA
0.2156
0.1714
—
ptsG pykFA
0.1366
6.834
0.231
ptsG mqo
0.1884
0.1714
—
ptsG sdhA
0.1884
0.1714
—
ptsG aceBA
0.1884
0.1714
—
pykFA sdhA
0.2156
0.1714
—
pykFA aceBA
0.2156
0.1714
—
mqo sdhA
0.2156
0.1714
—
mqo aceBA
0.2156
0.1714
—
sdhA aceBA
0.2156
0.1714
—
ptsG pfl ldhA
0.1611
0.6856
—
ptsG pykF pykA pfl
0.1219
9.1236
0.503
ptsG pykF pykA pfl ldhA
0.1219
9.1236
0.503
a
Calculated as succinic acid/(succinic acid
+
lactate
+
formate
+
acetate
+
ethanol).
Figure 7.13
Computationally predicted tradeoff curves for several in silico
mutants. Closed circles, wild-type; open circles, D
ptsG
; closed triangles, D
pflB
;
open triangles, D
ptsG
D
pykFA
; close squares, D
ptsG
D
pykFA
D
pflB
; open squares,
D
ptsG
D
pflB
D
ldhA
; closed diamonds, D
ptsG
D
pykFA
D
pflB
D
ldhA
under aerobic
condition; open diamonds, D
ptsG
D
pykFA
D
pflB
D
ldhA
under anaerobic
condition. Abbreviations:
ptsG
, phosphotransferase systems;
pyk
, pyruvate
kinase;
pflB
, pyruvate formate-lyase;
ldhA
,
D
-lactate dehydrogenase.
223
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