Biology Reference
In-Depth Information
Figure 7.9 Overview of systems biotechnological research for the development
of improved organisms. Hypothesis-driven computational modeling and
simulation, and technology-driven high-throughput x-omic experiments, are
combined to generate new knowledge, which is used to fine-tune the model
and design new experiments. This process is iterated until one achieves the
goal of developing improved strains having desired traits.
models of a biological system of interest and rational experimental pro-
cedures, respectively, which complementarily interact with each other
for the generation of new knowledge [14,79,80]. Accumulation of ever-
increasing amounts of biological data ranging from DNA and protein
sequences to metabolic pathways results in the development of various
databases. These databases are used not only for extracting local bio-
logical information (e.g., identifying a gene or genes of interest based
on homology search) but also for larger-scale studies such as metabolic
network construction and analysis in model-driven research. Even
though our understanding of the genome is still far from complete,
Search WWH ::




Custom Search