Mapping the Genotype–Phenotype Relationship in Cellular Signaling Networks: Building Bridges Over the Unknown - Systems Biology: Networks, Models, and Applications - page 165

58. Sato, M., T. Ozawa, K. Inukai, et al. Fluorescent indicators for imaging pro-

tein phosphorylation in single living cells. Nature Biotechnology , 20(3):287-94,
2002.

59. Mochizuki, N., S. Yamashita, K. Kurokawa, et al. Spatio-temporal images of

growth-factor-induced activation of Ras and Rap1. Nature , 411(6841):1065-8,
2001.

60. Aebersold, R. and M. Mann. Mass spectrometry-based proteomics. Nature ,

422(6928):198-207, 2003.

61. Salomon, A. R., S. B. Ficarro, L. M. Brill, et al. Profiling of tyrosine phos-

phorylation pathways in human cells using mass spectrometry. Proceedings
of the National Academy of Sciences USA , 100(2):443-8, 2003.

62. Zhu, H. and M. Snyder. “Omic” approaches for unraveling signaling

networks. Current Opinion in Cell Biology , 14(2):173-9, 2002.

63. Nielsen, U. B., M. H. Cardone, A. J. Sinskey, et al. Profiling receptor tyro-

sine kinase activation by using Ab microarrays. Proceedings of the National
Academy of Sciences USA , 100(16):9330-5, 2003.

64. Dykxhoorn, D. M., C. D. Novina and P. A. Sharp. Killing the messenger: short

RNAs that silence gene expression. Nature Reviews Molecular Cell Biology ,
4(6):457-67, 2003.

65. Boutros, M., A. A. Kiger, S. Armknecht, et al. Genome-wide RNAi analysis

of growth and viability in Drosophila cells. Science , 303(5659):832-5, 2004.

66. Ideker, T., V. Thorsson, J.A. Ranish, et al. Integrated genomic and pro-

teomic analyses of a systematically perturbed metabolic network. Science ,
292(5518):929-34, 2001.

67. Palsson, B. and S. Bhatia. Tissue Engineering . Pearson Prentice Hall, Upper

Saddle River, N.J., 2004.

68. Ott, T. R., A. Pahuja, F. M. Lio, et al. A high-throughput chemotaxis assay

for pharmacological characterization of chemokine receptors: utilization of
U937 monocytic cells. Journal of Pharmacological and Toxicological Methods ,
51(2):105-14, 2005.

69. Zigmond, S. H. Ability of polymorphonuclear leukocytes to orient in gra-

dients of chemotactic factors. Journal of Cell Biology , 75(2 Pt 1):606-16, 1977.

70. Zicha, D., G. A. Dunn and A. F. Brown. A new direct-viewing chemotaxis

chamber. Journal of Cell Science , 99(Pt 4):769-75, 1991.

71. Edwards, B. S., T. Oprea, E. R. Prossnitz, et al. Flow cytometry for high-

throughput, high-content screening. Current Opinion in Chemical Biology ,
8(4):392-8, 2004.

72. Papin, J. A. and B. O. Palsson. The JAK-STAT signaling network in the

human B-cell: an extreme signaling pathway analysis. Biophysical Journal ,
87(1):37-46, 2004.

73. Ideker, T., T. Galitski and L. Hood. A new approach to decoding life: systems

biology. Annual Review of Genomics and Human Genetics , 2:343-72, 2001.

74. Epstein, R. J. Human Molecular Biology: An Introduction to the Molecular Basis

of Health and Disease . Cambridge University Press, New York, 2003.

75. Wen, X., S. Fuhrman, G. S. Michaels, et al. Large-scale temporal gene

expression mapping of central nervous system development. Proceedings of
the National Academy of Sciences USA , 95(1):334-9, 1998.

76. Shvartsman, S. Y., H. S. Wiley, W. M. Deen, et al. Spatial range of autocrine

signaling: modeling and computational analysis. Biophysical Journal ,
81(4):1854-67, 2001.