Biology Reference
In-Depth Information
proteins may interact with
determining protein-protein
congruence exists between
one another. Proteins are
interactions.
different data sets.
tagged such that interactions
Very sensitive, and therefore
Exhibits high degree of false
result in the expression of
capable of detecting
positives, as some proteins are
a reporter gene.
interactions that are not
spatially or temporally
observed through other
segregated in vivo.
methods.
Limited to proteins that can be
Highly scalable, enabling the
localized to the nucleus such
rapid generation of large
that the reporter gene is
amounts of data.
expressed.
Some variants of this
technique can be used for
membrane proteins.
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