Biology Reference
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Figure 4.13
(a) One-zero null hypothesis data: scatter plot of signature
log
10
-tpm pairs (q
i
,
j
,q
i
,
j
′
), where replicates
j
and
j'
are biological replicates taken
at
t
0 (i.e., each q is the log of an aggregate tpm derived from two MPSS
replicates) for all signatures
i
that have one MPSS replicate measurement of
zero tpm counts in either
j
or
j'
(or both). Also plotted are equivalent points
for which
j
and
j
' are biological replicates taken at
t
=
4h. (b) Standard deviation
of measurement noise s as a function of signal level q for data shown in (a).
(c) Two-zero null hypothesis data: distribution of nonzero signature tpm
values taken from biological replicates taken at
t
=
0. Data taken from biological
replicate
j
where the aggregate tpm measurement in
j'
was zero and from
j'
where the aggregate tpm measurement in
j
was zero. Also plotted are
equivalent points for which
j
and
j
' are biological replicates taken at
t
=
=
4 h.
The dark shaded region is the significant data for
p
equal to 0.05.
127
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