Biomedical Engineering Reference
In-Depth Information
Presenilins:
A family of related transmembrane proteins that function as a part of the
gamma-secretase protease complex. Vertebrates have two presenilin genes, called
PSEN1 (located on chromosome 14 in humans), which encodes presenilin 1 (PS-1), and
PSEN2 (on chromosome 1 in humans), which codes for presenilin 2 (PS-2). Mutations
in the presenilin proteins are known to cause early ons
et al
zheimer's disease through
mechanisms which are still being elucidated.
Synaptic transmission:
Also called neurotransmission, an electric movement within synapses
caused by the propagation of nerve impulses.
Abbreviations
AD
Alzheimer`s disease
AMOG
adhesion molecule on glial
APP
amyloid precursor protein
Aβ
beta-amyloid peptide
CNS
central nervous system
CNTN1
contactin-1
CSF
cerebrospinal l uid
CTF2
C-terminal fragment 2
DCC
deleted in colorectal cancer
FAD
familial Alzheimer's disease
IgCAMs
cell adhesion molecules of the immunoglobulin superfamily
IgSF
immunoglobulin superfamily
LTP
long-term potentiation
MAG
myelin-associated glycoprotein
MDGA1
MAM domain-containing glycosylphosphatidylinositol
anchor
MOG
myelin-oligodendrocyte glycoprotein
NCAM-1
neural cell adhesion molecule 1
NCAM-2
neural cell adhesion molecule 2
Necl1
nectin-like molecule 1
Necl2
nectin-like molecule 2
Necl3
nectin-like molecule 3
Necl4
nectin-like molecule 4
NOTCH1
Notch homolog 1
NrCAM
neuron-glia-related cell adhesion molecule
NrCAM-2
neuron-glia-related cell adhesion molecule 2
OBCAM
opioid-binding cell adhesion molecule
Pcdh
protocadherins
