Biomedical Engineering Reference
In-Depth Information
Table 2
Members of the integrin superfamily in the brain
Molecule
Ligand
Distribution
α1β1
Laminin, collagen, tenascin
Glial, perineurium, Schwann,
endothelial cells
α2β1
Laminin, collagen
Endothelium, astrocytes,
Schwann cells
α3β1
Laminin, collagen, i bronectin
Endothelium, epithelium,
astrocytes
α4β1
α4β1, α4β7, i bronectin,
Endothelial, neural-crest-
VCAM-1, thrombospondin-1
derived cells
α5β1
Fibronectin, murine L1
Epithelium, endothelium,
astrocytes
α6β1
Laminin
Epithelium, endothelium,
T-cells, glia
α8β1 (CD-/CD29;
Fibronectin, vitronectin,
Epithelium, neurons,
VLA-8)
tenascin
oligodendroglia
αvβ1
Vitronectin, i bronectin,
Oligodendroglia
collagen, von Willebrandt
factor, i brinogen
αL β2 (LFA-1α;
ICAM-1, ICAM-2, ICAM-3
Macrophages, T-cells, microglia
CD11a)
αM β2 (CD11b)
ICAM-1, Factor X, iC3b,
Macrophages, microglia
i brinogen
αX β2 (CD11c)
iC3b, i brinogen
Dendritic cells, microglia
αv β3 (CD51/CD61)
Fibronectin, osteopontin, von
Glia, Schwann cells, endothelium
Willebrandt`s factor, PECAM-1,
vitronectin, i brinogen, human
L1, thrombospondin, collagen
α 6 β4
Laminin
Endothelium, epithelium
αv β6
i bronectin,
Epithelium, oligodendroglia
i brinogen
αv β8
Vitronectin
Schwann cells, endothelium
oligodendroglia, brain synapses
h is table shows the important members of the brain integrin superfamily of cell-surface adhesion molecules
consisting of eight dif erent β-chains and 18 dif erent α-chains that assemble as heterodimers to mediate cell-cell
and cell-matrix interactions. VCAM-1, vascular cell adhesion molecule 1; ICAM, Inter-cellular adhesion molecule;
PECAM-1, platelet/endothelial cell adhesion molecule 1; iC3b, the proteolytically inactive product of the complement
cleavage fragment C3b. h e table is based on data presented on the website
http://neuromuscular.wustl.edu/lab/
adhesion.htm
Neuronal dystrophy is associated with synaptic loss in culture and in the AD
brain, and is a unique pathological feature of AD. h e ability of the neuron to
respond dynamically to extracellular cues is reminiscent of plasticity mechanisms.
