Biomedical Engineering Reference
In-Depth Information
30
CHAPTER
Soluble Adhesion Molecules in Brain
Infarction
Toshitaka Umemura
1, *
, Takahiko Kawamura
2
,
Toshimasa Sakakibara
3
, Nigishi Hotta
4
and Gen Sobue
5
1
Departments of Neurology, Chubu Rosai Hospital,1-10-6 Komei, Minato-ku,
Nagoya, 455-8530, Japan,E-mail:
t.umemura@bg7.so-net.ne.jp
2
Departments of Metabolism and Endocrine Internal Medicine, Chubu Rosai
Hospital, 1-10-6 Komei, Minato-ku, Nagoya, 455-8530, JAPAN,
E-mail:
Kawamura.hsc@chubuh.rofuku.go.jp
3
Departments of Neurology, Chubu Rosai Hospital,1-10-6 Komei, Minato-ku,
Nagoya, 455-8530, Japan, E-mail:
tsrfn@yahoo.co.jp
4
Departments of Metabolism and Endocrine Internal Medicine, Chubu Rosai
Hospital, 1-10-6 Komei, Minato-ku, Nagoya, 455-8530, Japan,
E-mail:
hotta@chubuh.rofuku.go.jp
5
Departments of Neurology, Nagoya University Graduate School of Medicine,65
Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan,
E-mail:
sobueg@med.nagoya-u.ac.jp
ABSTRACT
In brain ischemia, stimulation by various inl ammatory cytokines increases the
expression of adhesion molecules, which enhances interaction between leukocytes
and vascular endothelial cells. h ough this mechanism is considered important to
brain infarction, in particular cerebral small-vessel disease (SVD), it has not yet
been studied in detail. In this chapter, we primarily discuss the association between
brain infarction and microcirculation dysfunction in cerebral small vessels at the
acute and chronic phage.
