Biomedical Engineering Reference
In-Depth Information
SUMMARY
• Epidemiological studies have reported an inverse relation between high
intake of i sh and risk of ischaemic heart disease.
• n-3 PUFA have been shown to be cardioprotective in primary and
secondary intervention trials.
• Cellular adhesion molecules (CAMs) play a central role in the development
of atherosclerotic disease.
• In vitro studies have shown an inverse association between n-3 PUFA and
expression of CAMs.
• n-3 PUFA may also decrease the expression of pro-inl ammatory genes,
including transcriptional genes for CAMs.
• n-3 PUFA exert anti-inl ammatory actions by modulation of production
of anti-inl ammatory and pro-inl ammatory cytokines.
• Animal studies have inconsistently coni rmed an anti-atherosclerotic
ef ect of n-3 PUFA and a decreased expression of CAMs at er dietary
intervention with n-3 PUFA.
• Randomized, controlled trials of healthy subjects or patients with ischaemic
heart disease so far have reported diverging ef ects of supplements of n-3
PUFA on serum levels of sCAMs.
Abbreviations
AA
arachidonic acid (20:4, n-6)
CABG
coronary artery bypass grat
CAMs
cellular adhesion molecules
DHA
docosahexaenoic acid (22:6, n-3)
DM
diabetes mellitus
EPA
eicosapentaenoic acid (20:5, n-3)
IHD
ischaemic heart disease
MI
myocardial infarction
PCI
percutaneous coronary intervention
PUFA
polyunsaturated fatty acids
RCT
randomized controlled trial
sCAM
soluble cellular adhesion molecule
