Biomedical Engineering Reference
In-Depth Information
28
CHAPTER
Apolipoproteins and Cell Adhesion
Molecules
Chunyu Zheng
1
, Frank M. Sacks
2
and Masanori Aikawa
3, *
Department of Nutrition, Harvard School of Public Health (C.Z., F.M.S.), and the
Center for Excellence in Vascular Biology, Cardiovascular Division, Department
of Medicine, Brigham and Women's Hospital, Harvard Medical School (M.A.).
1
Department of Nutrition, Harvard School of Public Health, Building 2 Room
202B, 665 Huntington Avenue, Boston, MA 02115.
E-mail:
czheng@hsph.harvard.edu
2
Department of Nutrition, Harvard School of Public Health, Building 1 Room 201,
665 Huntington Avenue, Boston, MA 02115. E-mail:
fsacks@hsph.harvard.edu
3
Center for Excellence in Vascular Biology, Brigham and Women's Hospital,
Harvard Medical School, 77 Avenue Louis Pasteur, NRB741J, Boston, MA 02115.
E-mail:
maikawa@rics.bwh.harvard.edu
ABSTRACT
Cell adhesion molecules, by mediating the recruitment of circulating leukocytes
to the blood vessel wall and their subsequent adherence and transendothelial
migration, play critical roles in all stages of atherosclerotic lesion development.
Various inl ammatory stimuli induce expression of adhesion molecules. h is
chapter highlights the direct functions of apolipoproteins, surface constituents of
plasma circulating lipoproteins, in monocyte activation and vascular endothelium
dysfunction. Apolipoproteins regulate lipoprotein metabolism, and their
dysregulation closely associates with hypercholesterolemia, hypertriglyceridemia
and insulin resistance, dysmetabolic states that predispose patients at elevated
