Biomedical Engineering Reference
In-Depth Information
• AF-induced expression of VCAM-1 is higher in the let atrium than in the
right atrium.
• h e prothrombogenic process of endocardial remodeling can be
substantially attenuated by treatment with angiotensin receptor blockers.
• h is suggests that angiotensin II has a signii cant pathophysiological role in
endocardial remodeling and consecutive adhesion molecule expression.
• Experiments in chronic AF models are warranted to determine the long-
term ei cacy of ARBs in this process.
Abbreviations
ACE
angiotensin-converting enzyme
ADP
adenosine diphosphate
AF
atrial i brillation
Ang II
angiotensin II
ARB
angiotensin receptor blockers
AT1R
angiotensin II receptor type 1
ATP
adenosine triphosphate
Ca
2+
calcium ion
eNOS
endothelial nitric oxide synthase
GPIbα
gylycoprotein receptor 1 alpha
ICAM-1
intercellular adhesion molecule 1
IgSF-CAMs
immunoglobulin superfamily cell adhesion molecules
LOX-1
endothelial lectin-like oxidized low-density lipoprotein
receptor receptor
NADPH
nicotinamide adenine dinucleotide phosphate
NF-κB
nuclear factor kappa B
NO
nitric oxide
PSGL-1
P-selectin glycoprotein ligand 1
RAS
renin-angiotensin-system
ROS
reactive oxygen species
SR
sinus rhythm
TNFα
tumor necrosis factor alpha
TRAP
thrombin receptor activating peptide
VCAM-1
vascular cell adhesion molecule 1
vWF
von Willebrandt factor
