Biomedical Engineering Reference
In-Depth Information
Fig. 10
Impact of ischemia on cadherin/catenin localization in pSM2 cells. pSM2 cells made
ischemic by a mineral oil overlay model, demonstrating loss of E- and N-cadherin. Reprinted from
Covington
et al.
(2006), with permission.
Color image of this i gure appears in the color plate section at the end of the topic.
Fig. 11
Peri-nuclear translocation of b-catenin. Reperfusion (right) in a simulated ischemia
model (let ) in normal rat kidney causes translocation of b-catenin (red) to a perinuclear location
(nucleus in blue).
Color image of this i gure appears in the color plate section at the end of the topic.
by the i nding that HgCl
2
-induced nephrotoxicity resulted in disruption of the
N-cadherin/β-catenin/α-catenin complex in the proximal tubular epithelium
(Jiang
et al.
2004), while both bismuth and cadmium (Prozialeck and Lamar 2005)
are also associated with alterations in the cellular localization of cadherins and
catenins in the kidney.
