Adhesion Molecules and Oxidized Low-density Lipoprotein - Adhesion Molecules - page 399

Fig. 4 Structure of scavenger receptors expressed in vascular endothelial cells. At least seven
scavenger receptors have been detected as illustrated above. Specii c domains are emphasized by
the codes indicated in the i gure. SRCL, scavenger receptor with C-type lectin; SR-BI, scavenger
receptor BI; LOX-1, lectin-like oxidized LDL receptor 1; SREC-I, scavenger receptor expressed on
endothelial cell I; SR-PSOX, scavenger receptor for phosphatidylserine and oxidized lipoprotein;
FEEL-1, fasciclin, epidermal growth factor (EGF)-like, laminin-type EGF-like and link domain-
containing scavenger receptor 1.

Table 1 Key points of scavenger receptors expressed in human vascular endothelial
cells
Scavenger receptors Endothelial cells

SRCL/CL-P Umbilical artery and vein

SR-BI Umbilical vein

CD36 Dermal microvessels, especially small microvessels in the deep

vascular plexus
LOX-1 Aortic, carotid, thoracic, and coronary arteries and veins
SREC-I Umbilical vein
SR-PSOX Umbilical vein
FEEL-1/stabilin-1/ CLEVER-1 Umbilical vein, dermal lymphatic vessels
h e scavenger receptor family can be broadly classii ed into eight subclasses. At least seven scavenger receptors have
been detected in human vascular endothelial cells as listed above. SRCL, scavenger receptor with C-type lectin. CL-
P1, collectin placenta 1. SR-BI, scavenger receptor BI. LOX-1, lectin-like oxidized LDL receptor 1. SREC-I, scavenger
receptor expressed on endothelial cell I. SR-PSOX, scavenger receptor for phosphatidylserine and oxidized lipoprotein.
FEEL-1, fasciclin, epidermal growth factor (EGF)-like, laminin-type EGF-like and link domain-containing scavenger
receptor 1. CLEVER-1, common lymphatic endothelial and vascular endothelial receptor 1.