Biomedical Engineering Reference
In-Depth Information
G-CSF
granulocyte colony-stimulating factor
HCELL
hematopoietic cell E-/L-selectin ligand
ICAM-1
intercellular adhesion molecule 1
IL-1
interleukin 1
IL-8
interleucin 8
LFA-1
lymphocyte function-associated antigen 1
MAC-1
macrophage antigen 1
MMP
metalloproteinase
NCAM
neural adhesion molecules
NOD/SCID mice
Non-obese diabetic mice
PECAM
platelet endothelial cell adhesion molecule
RARα
retinoic acid receptor α
SCF
stem cell factor
SDF-1
stroma derived factor 1
sLe
x
sialyl-Lewis
x
-like
VLA
very late antigen
Key Facts about Hematopoiesis
1. Hematopoiesis is the process by which blood cells are formed.
2. All mature blood cells derive from a pool of progenitors known as
hematopoietic stem cells, which, at er birth, reside in the bone marrow
and may circulate.
3. Hematopoietic stem cells have the capacity for unlimited or prolonged
self-renewal
that can give rise by asymmetric division to a progenitor cell
characterized by loss of self-renewal capacity.
4. h ere are two main hematopoietic lineages that are dif erentiated from
immature progenitors which derive from the hematopoietic stem cells: (a)
the lymphoid progenitors that ultimately give rise to B-cells and T-cells
and (b) the myeloid progenitors that eventually give rise to monocytes,
platelets, granulocytes/monocytes (neutrophils, eosinophils, basophils),
and erythrocytes.
Key Facts about Leukemia
1. Leukemia is a malignant and monoclonal proliferation of hematopoietic
cells. In leukemia, bone marrow is ini ltrated by a large number of abnormal
progenitors leading to a block of the production of normal white blood
cells.
