Adhesion Molecules in Normal Hematopoiesis and Leukemia - Adhesion Molecules - page 359

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CHAPTER

Adhesion Molecules in Normal
Hematopoiesis and Leukemia

Mirela de Barros Tamarozzi 1 and Eduardo Magalhães Rego 2
1,2 Hematology Division, Department of Internal Medicine, and National Institute
of Science and Technology on Cell Therapy, Medical School of Ribeirão Preto,
University of São Paulo, Brazil
Additional author : 1 Ms.C. Hematology Division, Department of Internal Medicine,
and National Institute of Science and Technology on Cell Therapy, Medical
School of Ribeirão Preto, University of São Paulo, Brazil, E-mail: tamarozzi@
usp.br
2 M.D., Ph.D, Hematology Division, Department of Internal Medicine, Medical
School of Ribeirão Preto, and National Institute of Science and Technology on
Cell Therapy, Av Bandeirantes 3900, CEP 14049-900, Ribeirão Preto, SP, Brazil,
E-mail: [e-mail]
Institution communication : Divisão de Hematologia, Departamento de Clínica
Médica, Faculdade de Medicina de Ribeirão Preto, Av Bandeirantes 3900,
CEP 14049-900, Ribeirão Preto, SP, Brazil,
E-mail: [e-mail] .
Alternative contact : Ms Dalva Cato

ABSTRACT

h e fate of hematopoietic stem cells is largely regulated by interactions with the
bone marrow environment. h is cross-talk mainly occurs in two niches: along the
endosteal surface of trabecular bone in close proximity to osteoblasts (osteoblastic
niche) and the endothelial cells that line blood vessels (vascular niche). Adhesion
molecules are expressed by stromal cells, extracellular matrix, hematopoietic
stem cells and committed hematopoietic progenitors and play a pivotal role in
the distribution of hematopoietic stem cells in the bone marrow, regulation of