Biomedical Engineering Reference
In-Depth Information
(A)
(B)
(C)
Fig. 3
Tumor cell adhesion to endothelium. (A) Studies indicate that tumor cells express
adhesion molecules similar to those found on leukocytes, suggesting that tumor cells may adhere
by means of the rolling mechanism. (B) h e tumor cells may directly interact with endothelial cells,
or (C) they may interact indirectly by adhering to leukocytes, which then adhere to endothelial
cells.
h is chapter will focus on the role of endothelial adhesion molecules in cancer
progression. We will discuss the role of endothelial cell adhesion molecules in the
host response to the primary tumor. Ini ltrating leukocytes have been shown in
many studies to function as both pro- and anti-tumor, indicating that they have
a major role in tumor progression. Ini ltrating leukocytes have also been shown
to be pro-metastatic through production of proteinases and cytokines, mediating
intravasation of tumor cells, or clusters of tumor cells and leukocytes. We will
then discuss the role of endothelial cell adhesion molecules in extravasation of
tumor cells at secondary sites. Lastly, we will focus on specii c endothelial cell
