Adhesion Molecules in Skin - Adhesion Molecules - page 285

Table 2 Endothelial molecules involved in leukocyte adhesion and transmigration

Tethering Rolling Activation Adhesion Diapedesis Chemotaxis

Selectins Selectins CC chemokines IgSF IgSF CC chemokines

E-selectin E-selectin CCL1, 2, 5, 11, ICAM-1 PECAM-1 CCL1, 2, 5, 11, 13,

P-selectin P-selectin 13, 26, ICAM-2 ICAM-2, -3 20, 26

17 (TARC), VCAM-1 JAM A, B, C 17 (TARC),

27 (CTACK) 27 (CTACK)

s-Le x s-Le x Cadherins

PNAd PNAd VE-cadherin CC chemokines

CXCL10, 11, 12

IgSF IgSF Type II
VCAM-1 VCAM-1 membrane
ICAM-3 protein CX 3 C chemokine
CD99 CX 3 CL1
Endothelial sites express variable adhesion receptors and chemoattractant compounds that will direct recruitment of
specii c leukocyte subsets. h e molecules primarily involved in T cell homing to skin are listed in bold type. (Source:
RCF, unpublished.)

Blood

Skin

T EM Skin
CCR7+
CD62L+
CCR4+
CLA +

Skin draining LN

Dendritic cell

CCR7+
CXCR4+

T N

T CM CD62L+

CCR7+
CD62L+
CCR4+
CLA+ -

CCR7+
CD62L+
CCR4+
CLA+

re-education

Organ X draining LN

T REGSkin T EM X

CCR7+
CD62L+
CCRX+

CCR7+
CD62L+
CCR4+
CLA+
FOXP3+

Organ X

Fig. 2 Immune surveillance and T cell education. Mature dermal dendritic cells (dDC) and/or
Langerhans cells (LC) migrate into skin draining lymph nodes, where they prime and imprint a
skin homing phenotype on antigen-specii c naive T cells (T N ). Skin ef ector memory T cells (T EM
skin) and skin regulatory T cells (T REG skin) enter the circulation at er leaving the lymph node,
and home specii cally to the skin to at ack the invading pathogen (T EM ) or restrain the immune
response (T REG ) in the skin. Central memory T cells (T CM ) leave skin draining lymph nodes and
enter lymph nodes of other organs (X) where they can become re-educated to become ef ector
cells of other organs (T EM -X). (Source: RCF, unpublished.)