Biomedical Engineering Reference
In-Depth Information
(b) the ability of OPG to act as a bridge between endothelial cells and
leukocytes.
4. Studies in mouse models did not support a major role of OPG in diseases
associated with inl ammation and even suggested protective ef ects.
Whether these i ndings represent species dif erences from humans or
other experimental ef ects is currently unclear.
Definition of Terms
Angiopoietin-2:
A regulator stored in Weibel-Palade bodies within the endothelium that,
evidence now suggests, plays an important role in controlling the activation state of the
endothelium.
Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1)
and E-selectin (CD62E):
Endothelial expressed adhesion molecules important in stages
of leukocyte adhesion to the endothelium.
Leukocytes:
White blood cells that are key components of the immune response. h ey
defend the body against infection and bacteria.
Osteoprotegerin:
A soluble glycoprotein originally identii ed to protect bone from
breakdown by inhibiting osteoclasts. Subsequently it has been associated with a wide
range of human diseases.
RANKL:
A regulator of bone remodelling; RANK is the receptor for this molecule.
References
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