Biomedical Engineering Reference
In-Depth Information
Acknowledgements
We acknowledge those colleagues whose work we were unable to cite due to space
limitations.
Abbreviations
αI /αA
insertion domain of integrin α chains
C domain
constant immunoglobulin domain
CAM
cell adhesion molecule
CBD
catenin binding domain
CRD
carbohydrate recognition domain
C-terminal
carboxyl-terminal
DSC
desmocollin
DSG
desmoglein
EC domain
extracellular cadherin domain
ECM
extracellular matrix
EGF
epidermal growth factor
FNIII domain
i bronectin type III domain
I domain
intermediate immunoglobulin domain
ICAM-1
intercellular adhesion molecule 1
ICS
intracellular cadherin segment
Ig
immunoglobulin
IgSF
immunoglobulin superfamily
JMD
juxtamembrane domain
NCAM
neural cell adhesion molecule
N-terminal
amino-terminal
PSI domain
plexin-semaphorin-integrin domain
SCR
short consensus repeat
V domain
variable immunoglobulin domain
Definition of Terms
Cadherins:
Cell surface proteins that mediate calcium dependent cell-cell adhesion, each
containing an extracellular cadherin (EC) repeat.
Heterophilic binding:
h e binding by an adhesion molecule to a dif erent molecule.
Homophilic binding:
h e binding of an adhesion to molecule itself on another cell.
Ig-like domain:
h e basic structural unit of IgSF members, consisting of two sheets of anti-
parallel β strands which form a sandwich structure, stabilized by a disuli de bridge.
Immunoglobulin superfamily (IgSF):
A family of proteins that contain at least one Ig-like
domain.
Integrins:
Cell adhesion molecules mediating cell-cell and cell-matrix adhesion and
consisting of two non-covalently bound subunits (α and β).
