Adhesion Molecules and Smoking - Adhesion Molecules - page 256

sICAM-1 between the dif erent presentations of coronary artery disease, however,
are not dif erent from each other, suggesting a role for ICAM-1 in the initiation of,
rather than progression of, atherosclerosis. Once atherosclerosis is established, the
elevation of sICAM-1 becomes stable.
In healthy individuals, sICAM-1 is predictive of future cardiovascular events.
Multiple secondary analyses of data from prospective studies (Table 1) have
examined the association between sICAM-1 and CVD and atherosclerosis
(Table 2) . Although these studies have not specii cally examined the association
of smoking with adhesion molecule expression, the analyses suggest that ICAM-1
mediates the initiation of CVD.

sICAM-1 and Healthy Men

Table 1 Select epidemiological studies of cardiovascular disease

Study Population Study design Outcomes of

interest

h e Prospective European (France and Prospective cohort Fatal AMI

Epidemiological Northern Ireland) apparently CD

Study of Myocardial healthy men, aged 50-59 yr CHD

Infarction (PRIME) with history of CHD

N=9,758

Physician's Health Apparently healthy male Prospective, CHD

Study U.S. physicians randomized PAD

N=22,071 double-blind trial Cancer

of aspirin and beta-

carotene for primary

prevention

h e Atherosclerosis Adults aged 45-64 yr Prospective cohort CHD

Risk in Communities from four U.S. communities CVA

Study (ARIC) (Forsyth County, NC; Jackson,

N=15,792 MS; northwestern suburbs of

Minneapolis, MN; Washington

County, MD)

Women's Health Study Apparently healthy U.S. Placebo-controlled CVD

N=28,263 middle-aged women prevention trial Cancer

AMI, acute myocardial infarction; CD, cardiac death; CHD, coronary heart disease; PAD, symptomatic peripheral
artery disease; CVA, cerebral vascular accident/stroke.

A nested case control study of the data from the PRIME study demonstrated
that elevated sICAM-1, but not sVCAM-1, in healthy men was predictive of
the development of cardiac disease. h is association remained at er controlling
for traditional risk factors for coronary atherosclerosis including smoking and