Adhesion Molecules in Kidney Diseases - Adhesion Molecules - page 248

CONCLUSION

Adhesion molecules play a critical role in the pathophysiology of a variety of
kidney disorders including glomerulonephritis, tubulointerstitial nephritis, renal
cysts, acute and chronic renal failure, hemodialysis membrane incompatibility
reactions and kidney transplant rejection. Further knowledge of the molecular
basis for adhesion molecules may not only shed light on the basic mechanism of
inl ammation, but also enhance understanding of other biological processes and
suggest novel strategies for therapeutic intervention.

Abbreviations

ADPKD autosomal dominant polycystic kidney disease

ARF acute renal failure

CAD chronic allograt dysfunction

CAPD continuous ambulatory peritoneal dialysis

C-ANCA cytoplasmic antineutrophil cytoplasmic antibodies

cDNA complementary deoxyribonucleic acid

CGN crescentic glomerulonephritis

ECM extracellular matrix

ELAM endothelial cell-leukocyte adhesion molecule

GN glomerulonephritis

GPIIb platelet glycoprotein

HD hemodialysis

ICAM intercellular adhesion molecule

IgAN IgA nephropathy

LFA-1 leukocyte function-associated molecule 1

MG membranous glomerulonephritis

MPO myeloperoxidase

NEPH nephrin

P-ANCA perinuclear antineutrophil cytoplasmic antibodies

PECAM platelet-endothelial cell adhesion molecule

RPGN rapidly progressive glomerulonephritis

TGF-β1 transforming growth factor-β 1

TNF-α tumor necrosis factor-α

TJ tight junction

VCAM vascular cell adhesion molecule

VE-cadherin vascular endothelial cadherin

VLA very late antigens

ZO zonula occludens