Biomedical Engineering Reference
In-Depth Information
60.0
60.0
60.0
Interaction p=0.008
Interaction p=0.008
55.0
55.0
55.0
50.0
50.0
50.0
45.0
45.0
45.0
40.0
40.0
40.0
35.0
35.0
35.0
100
100
100
110
110
110
120
120
120
130
130
130
140
140
140
150
150
150
Systolic BP Tertiles (mmHg)
Systolic BP Tertiles (mmHg)
Systolic BP Tertiles (mmHg)
60.0
60.0
Interaction p=0.034
Interaction p=0.034
55.0
55.0
50.0
50.0
45.0
45.0
40.0
40.0
35.0
35.0
60
60
70
70
80
80
90
90
100
100
Diastolic BP Tertiles (mmHg)
Diastolic BP Tertiles (mmHg)
Fig. 4
sE-selectin concentrations in women and men by tertiles of blood pressure (BP). Adjusted
for age, ethnicity, body mass index and smoking (geometric means and 95% coni dence intervals).
Women (triangles); Men (circles). In women < 50 years a 10 mmHg increase in systolic blood
pressure is associated with a 7.4% increase in sE-selectin. Produced from author's original data
(see also Miller
et al.
2004).
may therefore have a dif erent role in the development of CHD. Given the clear
gender dif erences observed and the interaction with age, it is also possible that
dif erent mechanisms may operate in men and women. h is needs to be examined
more carefully.
Adhesion Molecules, Glucose Intolerance, Insulin Resistance
Studies have reported that adhesion molecule levels are increased in individuals
with T2DM and these relationships are discussed in a separate chapter. A positive
relationship between both sE-selectin and sP-selectin and glucose has been
reported in the Stanislas study (Ponthieux
et al.
2004). A similar observation was
