Biomedical Engineering Reference
In-Depth Information
60.0
55.0
50.0
45.0
40.0
35.0
0.75
0.8
0.85
0.9
0.95
1
WHR tertiles
60.0
55.0
50.0
45.0
40.0
35.0
20
25
30
35
BMI tertiles
Fig. 3
sE-selectin levels by tertiles of waist-hip ratio (upper panel) and tertiles of body mass
index (lower panel) in 664 individuals from the Wandsworth Heart and Stroke Study. Adjusted
for age, sex, ethnicity, and smoking. Results are geometric means and 95% CI. P < 0.001 for both.
Adapted from Miller and Cappuccio (2006), with permission.
individuals with elevated levels of both molecules had an almost 2.5-fold increased
risk of CHD (Shai
et al.
2006).
sICAM-1 and sE-selectin were signii cantly correlated with BMI and measures
of visceral, but not subcutaneous, fat in morbidly obese individuals both before
and one year at er bariatric restrictive surgery (Pontiroili
et al.
2008). By contrast,
a study comparing obese and non-obese type 2 diabetes mellitus patients
(T2DM) did not i nd any relationship between sICAM-1 and sVCAM-1 and BMI
(Matsumoto
et al.
2002). Furthermore, while sE-selectin levels were signii cantly
and independently related to BMI, they were not independently related to regional
fat distribution. h ese results are consistent with the idea that obesity may induce
endothelial activation or increased shedding of cell surface E-selectin leading to
subsequent increase in sE-selectin levels. In another study, in non-diabetic obese
women, sICAM-1 and sE-selectin were positively correlated with measures of
central obesity. Weight reduction resulted in a decrease in these adhesion molecules
that was explained by a change in trunk fat mass (Ito
et al.
2002). h e relationship
between adhesion molecules and weight loss are discussed in chapter 14.
