Adhesion Molecules in Obesity and Metabolic Syndrome - Adhesion Molecules - page 201

Dyslipidemia

Abdominal adiposity Abdominal adiposity Hypertension Hypertension High glucose High glucose Insulin Resistance Insulin Resistance

Endothelial dysfunction Endothelial dysfunction

Accumulation of macrophages
and low-density lipoproteins

Accumulation of macrophages
and low-density lipoproteins

Toll-like receptors Toll-like receptors

NF- NF- k B activation

Adhesion molecule and cytokine expression Adhesion molecule and cytokine expression

Recruitment of monocytes and T-cells
Differentiation of macrophages

Recruitment of monocytes and T-cells
Differentiation of macrophages
Internalization of lipoproteins

Cardiovascular and Coronary Heart Disease Cardiovascular and Coronary Heart Disease

Fig. 1 Obesity, metabolic syndrome and cellular adhesion molecules. Endothelial dysfunction
acting through the toll-like receptor pathway may lead to the development of cardiovascular
disease and coronary heart disease (M.A. Miller, unpublished).