Biomedical Engineering Reference
In-Depth Information
11
CHAPTER
Adhesion Molecules in Decompression
Sickness and Ischemia Reperfusion
Injury
Nancy J. Bigley
1,*
and Barbara E. Hull
2
1
Professor of Microbiology and Immunology, Department of Neuroscience, Cell
Biology, and Physiology; and the Department of Pathology, Boonshoft School of
Medicine, 3640 Colonel Glenn Highway, Dayton, Ohio 45435,
E-mail:
nancy.bigley@wright.edu
2
Professor of Biological Sciences, Department of Biological Sciences; and the
Department of Medicine, Boonshoft School of Medicine, Wright State University,
3640 Colonel Glenn Highway, Dayton, Ohio 45435,
E-mail:
barbara.hull@wright.edu
Departmental contact
: Kimberly Hagler, Department of Neuroscience, Cell
Biology and Physiology, Boonshoft School of Medicine, Wright State University,
3640 Colonel Glenn Highway, Dayton, Ohio 45435,
E-mail:
kimberly.hagler@wright.edu
ABSTRACT
Cell adhesion molecules (CAMs) are the receptors and co-receptor ligands
orchestrating the orderly migration of hematopoietic cells throughout the body
and through endothelia in normal homeostasis and in pathological states. In this
chapter, we examine the role of tissue injury as the trigger for decompression
sickness (DCS) and ischemia-reperfusion (I/R) injury, pathologies in which
tissue hypoxia and inl ammation initiate changes in CAMs. Expression of CAMs
is upregulated on injured/inl amed vascular endothelia, and the transmigration
into the injured tissue sites of leukocytes bearing co-receptor ligands. h e various
inducers of increased CAM expression by vascular endothelia include noxious
tissue injury products (reactive oxygen species) as well as molecules secreted by the
inl ammatory blood cells and inl amed endothelia cells (inl ammatory cytokines).
