Feature, Structure and Classifi cation of Adhesion Molecules: An Overview - Adhesion Molecules - page 6

Fig. 2 Dimerization structure of intercellular adhesion molecule (ICAM-1). (A) Schematic of
cis -dimerization of two ICAM-1 molecules (orange and blue), interactions of Ig-like domains four
and i ve (D4, D5) are shown. (B) Ribbon diagram of two ICAM-1 dimers. h e interaction of Ig-
like domains D1 and D2 of one molecule from each dimer with its neighbor forms the binding
site for the aA domain of aL integrin (green) (PDB code: 1MQ8) (Shimaoka et al. 2003). An
approximate alignment of the D1-D2 structures with the dimer of D3-D5 (PDB code: 1P53)
(Yang et al. 2004) is shown. Yellow sulfur molecules indicate the position of disuli de bonds.
Divalent cations (Mg ++ ) are in pink. Figure adapted from Yang et al. (2004).
Color image of this i gure appears in the color plate section at the end of the topic.