Adhesion Molecules and Neutrophil Migration - Adhesion Molecules - page 141

Fig. 2 Adhesive interactions involved in neutrophil migration across epithelial surfaces.
Neutrophils adhere to the basolateral surface through the ligation of CD11b/CD18 to several
molecules, including fucosylated glycoproteins and JAMs. However, the epithelial ligand to
CD11b/CD18 has yet to be identii ed. Following adhesion, neutrophils transmigrate across the
epithelium by taking a paracellular route that is primarily mediated by CD47. Neutrophil JAML
also binds CAR. Once the neutrophils have completely migrated across the cell monolayer, they
adhere to the epithelial surface. h is process is mediated by the binding of CD11b/CD18 to
ICAM-1 and DAF to CD97. JAM, junctional adhesion molecules; CAR, coxsackie and adenovirus
receptor; ICAM-1, intracellular adhesion molecule 1; DAF, decay accelerating factor; CD, cellular
dif erentiation number.
across intestinal epithelial cell monolayers has served as the model for the study
of neutrophil-epithelial interactions, we also observed that both the type of
epithelial cell monolayer and the particular chemoattractant gradient imposed play
important roles in the adhesion molecules involved in transepithelial migration
(Hurley et al. 2008). Specii cally, our studies showed that neutrophil transepithelial
migration across airway epithelial cells (as compared to intestinal epithelial cells)
was more dependent upon CD44 and CD47 in response to imposed gradients of
fMLP and LTB 4 (Hurley et al. 2008). h us, our i ndings imply that the particular
chemoattractant gradient imposed, together with the type of epithelial monolayer,
somehow contribute to determining which adhesion molecules are involved in
transepithelial migration of neutrophils.
NEUTROPHIL ADHESION IN HEALTH AND DISEASE
Inl ammation is a localized protective response in vascular tissues induced by
microbial infection or cell and tissue injury, and the neutrophil is a key ef ector