Biomedical Engineering Reference
In-Depth Information
Leukocyte transmigration:
Transendothelial movement of leukocyte to the site of injury.
h is procedure plays an important role in the pathogenesis of inl ammatory reaction.
NF-κB:
A factor present in the cytoplasm in an inactive state and activated by
lipopolysaccharide and cytokines. Activation of NF-κB triggers the transcription of
genes involved in the inl ammatory response.
NO:
A small molecule produced by most cell types. NO is an antimicrobial agent, a
neurotransmitter and a vasodilator.
NOS:
h e enzyme that produces NO. h e substrate for this reaction is Arg and the products
are NO and citrulline.
NOS inhibitor:
Substance inhibits the NOS activities and inhibition of NO production.
L-NMMA is a non-selective NOS inhibitor. L-NAME is an inducible NOS inhibitor.
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