Chemistry Reference
In-Depth Information
melting, stable solid, which has been used to produce Methazole in high yield and
under mild conditions.
The urea fungicide Pencycuron can be prepared by aminolysis of carbamoyl
chloride 290 derived from N-cyclopentyl-N-4-chlorobenzylamine. The alternative
route involves addition of the secondary amine to phenyl isocyanate.
COCl
2
N
N
H
290
Cl
O
Cl
Cl
NH
2
NCO
N
Cl
O
NH
Pencycuron
The urea fungicide Benomyl is prepared with n-butyl isocyanate starting from the
amidine-carboxamide Carbendazim.
O
NH
H
N
O
O
N
cat
N
H
O
N
H
O
+
NCO
N
N
Carbendazim
Benomyl
NH
2
MeOCOCl
KSCN
+
+
NH
2
The fungicide Vinclozolin, a cyclic carbamate, is prepared with 3,5-dichlorophenyl
isocyanate.
3,5-Dichlorophenyl isocyanate is also the starting material for the synthesis of
the fungicide Iprodione.
