Chemistry Reference
In-Depth Information
O
O
O
O
O
O
HCOOH
DCC
N
N
S
S
HN
CHO
H
2
N
H
H
221
222
O
O
N
1. CH
2
Cl
2
,
O
O
N
2.
COCl
2
, -50°C
S
CN
H
223
ONa
O
O
S
O
N
S
N
H
224
O
H
Temocillin disodium
O
a
Zileuton [111406-87-2], anti-inflammatory, antiasthmatic, 5-lipoxygenase inhibitor, 229.
Phosgene or phosgene equivalents (trimethylsilyl isocyanate, diisopropyl azodi-
carboxylate) have been employed to prepare the hydroxy-urea compound Zileuton
[163-169].
HO
HO
COCl
2
, toluene
HCl, NH
3
or Me
3
SiNCO,
dioxane, NH
3
N
CO
NH
2
S
NH
S
NH
3
tBuOH
229
225
Zileuton
Ph
3
P, THF,
diisopropyl
azodicarboxylate
O
OH
S
O
OC
O
O
O
HN
O
S
N
O
O
O
226
227
228
