Chemistry Reference
In-Depth Information
chlorodibenzo[b, f ][1,4]thiazepine 208, the penultimate intermediate in the syn-
thesis of the drug 209 [153, 154].
1. H
2
, Raney-Ni,
O
Cl
EtOH
C
N
2.
COCl
2
,
N
NO
2
H
2
SO
4
toluene
S
100°C
S
S
206
207
208
OH
O
N
COOH
1/2
HOOC
N
N
209
Quetiapine fumarate
S
Raloxifene hydrochloride [82640-04-8], antiestrogen, prevention of osteoporosis, 213.
In
one reported method, phosgene is employed to chlorocarbonylate 6-methoxy-2-(4-
methoxyphenyl)benzo[b]thiophene 210 [155].
O
O
S
S
COCl
2
O
O
Cl
210
O
211
BCl
3
, DCE
0°C
N
* HCl
O
212
O
S
O
O
N
* HCl
O
213
Raloxifene hydrochloride
