Chemistry Reference
In-Depth Information
O
O
O
1.
COCl
2
, toluene
2. NH
3
, ethanol
N
N
N
H
O
O
2
2
174
175
176
Oxcarbazepine
H
H
O
OH
H
O
OH
H
COCl
2
O
N
O
N
H
H
H
H
H
177
178
EtBr
H
H
O
OH
O
OH
H
H
MeBr
O
O
N
Et
N
Et
_
H
H
Br
H
H
180
179
Oxitropium bromide
Perlapine [1977-11-3], hypnotic, 186. Phosgene is used to generate 2-isocyanato di-
phenylmethane 182, the precursor of the key lactam intermediate 183 [137].
AlCl
3
Di-Cl-benzene
COCl
2
N
C
O
H
2
N
NH
O
181
182
183
POCl
3
PhNMe
2
CH
3
N
HN
185
N
N
N
Cl
N
H
3
C
186
184
Perlapine